Cannes Longevity Docs Summit. Day Two!

Subscriber Recap – Day 2, The Morning Dispatch from Cannes

Day 2 at the Longevity Docs Summit opened with clarity and ended with confrontation — the good kind. We moved from hormone optimization to regenerative medicine, stem cells, exosomes, and therapeutic plasma exchange, all moderated by leaders who are actively reshaping clinical practice.

I never cease to be amazed by the fantastic people we have in this organization. Further I never cease to be blown away by their resilience and recovery strategies.

Malek and I Fighting for your right to Longevity Labs and Longevity Medicine!

Let’s walk through the key moments.

But first, please share this post with your family, friends and patients! It just may save a life, or at least, bring healing to those who need it!

---

Amy Killen’s Hormone Playbook: BEAST MODE Activated

Dr. Amy Killen opened the morning with a masterclass in hormone therapy, smart, fast, and rooted in clinical experience.

Her framework?

B.E.A.S.T. M.O.D.E.
A mnemonic for designing and delivering women’s hormone care in longevity practice:

• B – Bioidentical hormones: Always preferred over synthetic or conjugated formulations.

• E – Early treatment: Over 25 RCTs show early estrogen use prevents heart attacks, strokes, and hip fractures.

• A – All the parts: Every organ below the belt needs estrogen - age is not a contraindication.

• S – Systemic estrogen: Oral estrogen requires progesterone. Always balance.

• T – Testosterone: Only if needed. Don’t dose blindly.

• M – Mammograms: Screen appropriately but don’t confuse estrogen with breast cancer risk.

• O – Optimized, not “normal”: Lab values must be symptom-informed.

• D – Dose to prevent outcomes: Treat to reduce fracture, dementia, and cardiovascular risk, not to “hit a number.”

• E – Endometrial ultrasound: Use when in doubt about bleeding patterns. It’s simple and essential.

Her final challenge?
Only 5% of women who should be on estrogen are receiving it.
The fear instilled by the Women’s Health Initiative still haunts physicians, despite modern evidence that properly timed, properly formulated estrogen is cardioprotective and neuroprotective.

This is the kind of clinical clarity longevity medicine needs.

Did the last part change how you practice? Did it inspire you to ask your doctor about hormone replacement? If so, go back up and subscribe! I’ll bring even more inspiration and education your way!

---

Pradeep Albert: Caution, Precision, and Regenerative Logic

Dr. Pradeep Albert, interventional radiologist and regenerative medicine expert delivered a layered talk on stem cells, PRP, and exosomes. One of my mentors, Dr. Albert practices internationally and has trained countless physicians in regenerative techniques.

A few key takeaways:

• All stem cells are not equal.
  “Muse cells” a pluripotent mesenchymal-like population “may” offer superior plasticity, especially in environments where tissue repair needs to match structural demand.

• PRP is only as good as how it's made.
  He emphasized the importance of concentration, activation method, lymphocyte content, and delivery technique.
  A single-spin kit isn’t enough, the quality is in the process, not the product.

• Exosomes are powerful and risky.
  His warning was clear:

“If you don’t know what’s in the exosome, you shouldn’t be injecting it.”

Platelets release exosomes, too. “Millions per vial” means nothing without knowing what's actually in them. Without GMP oversight and functional analysis, you’re taking a gamble.

Dr. Albert will be publishing more on his CALVES framework for PRP protocols I’ll be covering that in a future post.

---

Dr. Sewell on Gene Therapy: Vectors and the Future

Dr. Sewell, another radiologist steeped in innovation, spoke about the use of adenoviral vectors in gene therapy and the coming wave of integrative regenerative genomic care.

This was a shorter session, which ran over quite a bit because it was packed with potential. More on this when his materials are released. In brief, he highlighted the topics in his book which is available on Amazon.

Would you consider Gene Therapy for Longevity? If no, why not?

During this talk he reviewed different gene selections. navigates readers through the intricacies of vector construction, promoter selection, gene optimization, and advanced applications, including gene editing technologies and targeted gene expression. We gained invaluable insights into:

• The strategic selection of AAV serotypes for tissue-specific gene delivery.
• Advanced engineering methods to enhance efficacy and minimize immune responses.
• Protocols for manufacturing and scaling vectors from laboratory research to clinical-grade production.
• Cutting-edge innovations and future directions in gene therapies targeting cancer, neurological disorders, and aging.

---

Stem Cells vs Plasma Exchange: The Moderated Panel

I had the privilege of moderating one of the most honest discussions of the conference it was a panel with:

• Dr. Dobri Kiprov, pioneer of therapeutic plasma exchange in the U.S.

• Dr. Matthias Bernow, CEO of Celco Labs, a leader in allogeneic stem cell therapy.

Here’s what came out of the conversation:

• Therapeutic plasma exchange (TPE) is supported by data — including randomized controlled trials showing improvements across multiple hallmarks of aging biomarkers. Dr. Kiprov reminded us that TPE has 30+ years of precedent and safety, yet few use it correctly. Many are charging exorbitant fees with little understanding.

• Allogeneic stem cells, harvested from donors aged 18–30, may have significant clinical benefit. Dr. Bernow acknowledged, however, that regulatory barriers remain high and costs can reach $30,000–$40,000 per treatment.

• The takeaway:

  • Demand GMP certification

  • Work with experienced clinicians

  • Avoid “stem cell tourism” unless your vendor can show quality control and safety data

  • Be wary of plasma exchange providers offering the service without proper filtration, volume exchange, or immunoglobulin management.

Both agreed: training, transparency, and patient-first ethics must lead the way.

Now we will move on to the most important part of this post, what you can do to act on these findings, for yourself, your loved ones or your patients!

1. Start Estrogen Early and Don’t Fear It

Key Insight: